Associate Scientist- Eislmayr Laboratory

Dr. Kevin Eislmayr is establishing a new laboratory, and we are seeking an Associate Scientist to lead the scientific and operational wet-lab program.This is a rare chance to help build a research operation from the ground up and to shape its direction, culture, and infrastructure. The Eislmayr laboratory studies host-pathogen interactions during Shigella infection. We combine microbiology, in vivo and human organoid-immune cell co-culture, and conditional genetic models to get insights into how invasion of intestinal epithelial cells shapes the immune responses behind protective immunity, and how those responses balance tolerance against inflammation in the gut. We also investigate how pathogens have evolved to counteract these responses. Our goal is to uncover the fundamental rules of epithelial-immune crosstalk and build a new translational framework for gut barrier defense.Key Responsibilities: Scientific ResearchLead and oversee the laboratory's cell culture and bacterial operations.Maintain mammalian cell lines and primary cultures, including intestinal organoids.Develop stable and CRISPR-engineered cell linesValidate and maintain bacterial stocks and generate bacterial knockout and reporter strainsPerform molecular biology and biochemical techniques including:CloningConjugationTransformationTransductionsTransfectionsImmunoprecipitationsWestern blottingConduct fluorescence and confocal microscopy experiments.Conduct in vitro and in vivo infection experimentsAnalyze data and maintain high-quality research documentationContribute to manuscripts, grant applications, and presentations at lab meetings, institutional seminars, and scientific conferences Laboratory Operations & ManagementLead the setup of the new laboratory, including equipment procurement, installation, and commissioningManage inventories, consumables, reagent stocks, and laboratory resources.Oversee service contracts and equipment maintenance activities.Ensure compliance with BSL-2 operations and institutional safety requirements, including SOPs, biosafety documentation, EH&S compliance, and training recordsManage SOP development, biosafety documentation, EH&S compliance, and training records.Maintain laboratory electronic notebooks, protocol repositories, and data management systems.Train, onboard, and mentor laboratory personnel in experimental procedures and best practices.Provide supervision and scientific guidance to junior staff and trainees as the laboratory grows. Minimum Education and/or Training:Bachelor’s degree in a relevant scientific areaMinimum Experience:7 + years of research experience is required5 + years of research experience is required with a Master’s2 + years of research experience is required with a PHDExperience leading and supporting research experiments preferredSome experience leading lab and scientific project coordination, maintenance, and other research support activities preferredExperience in guiding and training other laboratory personnel preferredProven performance in earlier role/comparable role Strongly PreferredCRISPR-based genome engineering and stable cell line generationProtein biochemistry (immunoprecipitation, western blotting)Organoid, air-liquid interface, or other tissue-derived model systemsExperience establishing or expanding a laboratoryELN administration or LIMS experienceSample preparation for flow cytometry, fluorescence microscopy, and confocal imagingTissue handling for in vivo based studies.Training and supervision of scientific staff and studentsHands-on experience with mammalian cell culture, including primary cellsExperience with microbiology and molecular biology techniques (cloning, transformation, transfection)Experience with BSL-2 laboratory operations and biosafety practicesWho You Are:You combine strong scientific expertise with a proactive, entrepreneurial mindset. You are comfortable working independently, building new processes, solving problems, and helping shape the culture and scientific direction of a growing program. You balance research excellence with lab management, and you bring strong project ownership, collaboration, mentorship, communication, and organizational skills.CompensationIn recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Associate Scientist- Eislmayr Laboratory.Explore our exceptional benefits!We are committed to a human-centered hiring experience. Technology may support portions of our process, but recruiting decisions involve human review and engagement. Learn more about our approach to AI.St. Jude is an Equal Opportunity EmployerNo Search FirmsSt. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.